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BN40218R-100ul
100ul
￥2360.00
交叉反應(yīng)：Mouse,Rat(predicted:Human,Pig) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA
BN40218R-200ul
200ul
￥3490.00
交叉反應(yīng)：Mouse,Rat(predicted:Human,Pig) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA
產(chǎn)品描述
| 英文名稱 | Fascin1 |
| 中文名稱 | 纖維束1抗體 |
| 別 名 | 55 kDa actin bundling protein; 55 kDa actin-bundling protein; Actin bundling protein; FAN 1; Fscin1; FAN1; Fascin 1; Fascin; Fascin homolog 1 actin bundling protein (Strongylocentrotus purpuratus); Fascin homolog 1; Fascin1; FLJ38511; FSCN 1; FSCN1; FSCN1_HUMAN; HSN; p55; Singed (Drosophila) like (sea urchin fascin homolog like); Singed drosophila homolog like; Singed like (fascin homolog sea urchin) (Drosophila); Singed like (fascin homolog sea urchin); Singed like protein; Singed-like protein; SNL; Strongylocentrotus purpuratus. |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 激酶和磷酸酶 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, Rat, (predicted: Human, Pig, ) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 55kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Fascin1:11-110/493 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011] Function: Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Subunit: Associates with beta-catenin. Interacts with PLXNB3. Subcellular Location: Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, invadopodium. Cytoplasm, cytosol. Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol. Tissue Specificity: Ubiquitous. Post-translational modifications: Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin. Similarity: Belongs to the fascin family. SWISS: Q16658 Gene ID: 6624 Database links: Entrez Gene: 6624 Human Entrez Gene: 14086 Mouse Omim: 602689 Human SwissProt: Q16658 Human SwissProt: Q61553 Mouse Unigene: 118400 Human Unigene: 289707 Mouse Unigene: 199526 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. FSCN1為細(xì)胞骨架肌動(dòng)蛋白的一種，該蛋白有蛋白結(jié)合,橋連、肌動(dòng)蛋白絲結(jié)合的功能。 主要參與細(xì)胞增殖、肌動(dòng)蛋白細(xì)胞骨架組織和生物發(fā)生、肌動(dòng)蛋白絲束形成。Fascin也是一種actin結(jié)合蛋白，它的功能是把F-actin聚集捆綁成束，與細(xì)胞的運(yùn)動(dòng)相關(guān)。病理情況下，各種惡性腫瘤細(xì)胞經(jīng)常高表達(dá)Fascin。 |
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